Addison Disease (Nursing)


Learning Outcome

  1. Understand the etiology of  Addison disease.
  2. Distinguish primary adrenal insufficiency from secondary adrenal insufficiency.
  3. Understand what system regulates mineralocorticoid levels.
  4. Differentiate between acute versus chronic adrenal insufficiency.
  5. Identify risk factors related to Addison's disease.
  6. List presenting factors.
  7. Understand lab abnormalities related to Addison disease.
  8. List common symptoms of Addison disease.
  9. Understand the use of imaging in the diagnosis of Addison disease.

Introduction

Addison disease is an acquired primary adrenal insufficiency, a rare but potentially life-threatening endocrine disorder that results from bilateral adrenal cortex destruction leading to decreased production of adrenocortical hormones, including cortisol, aldosterone, and androgens. Addison disease's insidious course of action usually presents with glucocorticoid deficiency followed by mineralocorticoid; however, it can present acutely,  often triggered by intercurrent illness. The term Addison disease is used when there is a primary adrenal insufficiency.

The most common cause of primary adrenal insufficiency is autoimmune adrenalitis (Addison disease), associated with increased levels of 21-hydroxylase antibodies.[1][2]

Nursing Diagnosis

  • The risk for infection related to immunocompromise as evidence by fever
  • The risk for volume depletion related to salt wasting as evidenced by low serum sodium
  • Alteration in perfusion related to hypotension as evidenced by low blood pressure

Causes

Any disease process which causes direct injury to the adrenal cortex can result in primary adrenal insufficiency (Addison disease). In most of the developed world, autoimmune destruction of the adrenal glands is the most common cause of Addison disease. Autoimmune destruction can be an isolated finding or part of autoimmune polyglandular endocrinopathies (type 1 and 2). Patients with the autoimmune adrenal disease are more likely to have polyglandular autoimmune syndromes.[3][4]

Other causes include infections (such as sepsis, tuberculosis, and HIV), bilateral adrenal hemorrhages (precipitated by coagulopathy, trauma, meningococcemia, neoplastic processes involving the adrenal glands. Rarer causes include sarcoidosis, amyloidosis, fungal infections, and genetic disorders such as adrenal leukodystrophy and Wolman disease.

Risk Factors

The incidence is 0.6/100,000 of the population per year. The total number of people affected by this condition is 4 to 11 per 100,000 of the population. It affects women more than men, the ages between 30 and 50 years are most affected.

Risk factors for the autoimmune (most common) type  of Addison's disease include other autoimmune diseases:

  • Type I diabetes
  • Hypoparathyroidism
  • Hypopituitarism
  • Pernicious anemia
  • Graves' disease
  • Chronic thyroiditis
  • Dermatis herpetiformis
  • Vitiligo
  • Myasthenia gravis

Assessment

Addison disease usually has an insidious and gradual onset of non-specific symptoms, often resulting in delayed diagnosis. In many cases, the diagnosis is made only after the patient is presented with an acute adrenal crisis (hypotension, hyponatremia, hyperkalemia, and hypoglycemia) precipitated by a stressful illness or triggering factors such as infection, trauma, surgery, vomiting, and diarrhea.

Addison disease can occur at any age but most often presents during the second to third decade of life. Symptoms may be quite non-specific and include fatigue, generalized weakness, weight loss, nausea, vomiting, abdominal pain, dizziness, tachycardia, and/or postural hypotension. Hyperpigmentation of skin and mucous membranes can be diffuse and most prominent in sun-exposed areas, often seen later in the course of the disease. This hyperpigmentation is due to elevated ACTH (as both ACTH and melanocyte-stimulating hormone (MSH) derived from the same precursor POMC) levels. Due to its variable presentation, a high index of suspicion for Addison disease is necessary when evaluating a conglomeration of non-specific symptoms, including unexplained fatigue, poor appetite, chronic abdominal pain, or weight loss, hyponatremia with or without hyperkalemia, and/or hypotension can be seen in Addisons disease. Addisonian crisis manifests with severe dehydration, refractory hypotension, and shock.

Addisonian crisis should be suspected in:

  • Patients receiving corticosteroids
  • Hemodynamically unstable patients despite aggressive fluid therapy
  • Septic shock

Evaluation

Hyponatremia is the most common initial laboratory finding and can be attributed to low cortisol and aldosterone levels. There is hypersecretion of ADH seen in cortisol deficiency triggers hypersecretion of ADH (due to hypovolemia). There may be enhanced hypothalamic secretion of corticotropin-releasing hormone (CRH), which contributes to ADH hypersecretion. Furthermore, the relative lack of cortisol removes the negative feedback for CRH and ADH production. Loss of aldosterone activity leads to natriuresis and potassium retention, thus further confounding electrolyte abnormalities, including life-threatening hyperkalemia.[5]

Hypoglycemia is multifactorial, including decreased oral intake and lack of glucocorticoids, which are needed for gluconeogenesis.

Typically, low random and stimulated cortisol and aldosterone levels are seen. A cortisol level less than 18 microgram/dL to 20 microgram/dL is considered diagnostic.

High ACTH level is diagnostic of primary adrenal destruction in the absence of ACTH resistance.

  •  Primary adrenal insufficiency: elevated ACTH
  •  Central adrenal insufficiency: abnormally normal or low ACTH

Increased plasma renin activity (PRA) can be seen, often late in the course of the disease (due to mineralocorticoid deficiency).

Anti-adrenal antibodies (such as 21-hydroxylase antibodies) serve as the markers of autoimmune destruction of the adrenal gland.

In suspected cases of adrenal hemorrhages, an abdominal CT scan may provide useful information.

A chest radiograph may reveal a small heart.

PPD should be performed to evaluate for tuberculosis.

Plasma very-long-chain fatty acid profile should be checked in cases where adrenal leukodystrophy is suspected based on family history or etiology is unclear after evaluation.

Medical Management

As Addison crisis is life-threatening, treatment should be initiated immediately when the diagnosis is suspected. However, blood samples should be saved for subsequent measurement of ACTH and cortisol levels. It is important to remember that a random measurement of plasma cortisol cannot confirm or exclude the diagnosis unless cortisol is unequivocally elevated. Elevation of ACTH with low cortisol is diagnostic of a primary adrenal problem. Measurement of cortisol in the ACTH stimulation test may be performed in equivocal cases where baseline lab evaluation cannot confirm the diagnosis. PRA is often elevated and is indicative of mineralocorticoid deficiency along with low aldosterone levels.[6][7][8]

Patients with adrenal crisis require the following:

  • Fluid resuscitation with intravenous (IV) normal saline (to correct volume depletion)
  • Dextrose (to correct hypoglycemia)
  • Hormone replacement to correct a lack of circulating glucocorticoid

The first-line hormonal treatment is hydrocortisone. As stress dose hydrocortisone has significant mineralocorticoid activity, fludrocortisone (synthetic mineralocorticoid) is usually not required in the acute phase. Stress dosing of hydrocortisone for acute adrenal crisis is 50 mg/m2 to 100 mg/m2, which can be given as a continuous infusion. The typical replacement fluid after a normal saline bolus is D5 normal saline. Beware that if left untreated, adrenal crisis can be fatal.

 The typical replacement oral dose of hydrocortisone is 10 to 15 mg/m2/day divided into two to three doses in adults. If compliance with frequent dosing is an issue, more potent glucocorticoids can be given less frequently, for example, prednisone QD-bid and dexamethasone QD; however, prednisone and dexamethasone do not have mineralocorticoid activity.

Also, mineralocorticoids should be replaced in the form of fludrocortisone at 50 micrograms/day to 200 micrograms/day (0.05 to 0.2 mg/day). In the presence of fever, infection, or other illnesses, the hydrocortisone dose should be doubled to account for stress response. This should be tailored according to the degree to stress. Identification and treatment of underlying causes such as sepsis are critical for an optimal outcome.

During replacement treatment, the following should be monitored to assess the adequacy of replacement therapy:

  • Signs and symptoms suggestive of adrenal insufficiency
  • Measurement of serum electrolytes, cortisol, and ACTH
  • Measurement of plasma renin activity.

Patients who are non-stressed can be treated with either hydrocortisone or prednisone with or without fludrocortisone.

Nursing Management

  • Assess patient and check vital signs
  • Gain intravenous access and start the normal saline infusion
  • Monitor lab values that include complete blood count, lactate, basic metabolic panel, and arterial blood gases
  • Draw blood cultures to investigate possible infection
  • Monitor changes and report changes to provider
  • Monitor intake and output
  • Assess and maintain adequate hydration
  • Administer medications as advised by the doctor
  • Assess and monitor skin pigmentation

When To Seek Help

  • Unstable vital signs
  • Changes in vital signs
  • Temperature higher than 101 F
  • Persistent hypotension

Outcome Identification

  • The patient does not have an infection 
  • The patient does not have volume depletion or dehydration
  • The patient does not have an adverse medication reaction
  • The issue is resolved and the patient is restored to baseline

Monitoring

  • Lab values
  • Blood pressure
  • Respiration
  • Temperature
  • Weight
  • Signs and symptoms of infection
  • Skin turgor and signs of dehydration
  • Electrolyte imbalance
  • Irregular heartbeat or dysrhythmia

Coordination of Care

Addison disease is a serious life-threatening disorder that affects many organs. If the diagnosis is delayed, it carries very high morbidity and mortality. Thus, the condition is best managed by an interprofessional team of healthcare workers that includes an endocrinologist, intensivist, infectious disease expert, gastroenterologist, and pharmacist. The education of patients is mandatory. Physicians, nurses, and pharmacists can do this. Nurses administer treatments, monitor patients, and provide updates to the team. Once the diagnosis is made, the outcomes depend on the primary cause. Any delay in starting corticosteroid treatment can lead to mortality rates exceeding 50%. All patients diagnosed with Addison disease must be urged to wear a medical alert bracelet. Patients should be educated on the signs and symptoms and contact their primary care provider at the slightest change in their vital signs. Finally, in times of stress, even a common cold, the patient should be told to double the steroid dose and see their primary care provider.[9][6] [Level 5]

Health Teaching and Health Promotion

Patients with Addison disease need to be counseled to understand the need for the following:

  • Medication compliance
  • Self-care, including adequate sodium intake in the diet, monitoring weight loss, and blood pressure
  • Get regular checkups with their clinician
  • Wear a medical alert ID bracelet or tag
  • Keep a dose of emergency cortisol at all times, and know when and how to administer the injection
  • Understand and be alert for the signs of an Addisonian crisis

Risk Management

  • Medication - correct dose at the right time to prevent adverse effect
  • Fall injury prevention
  • Infection prevention
  • Prevent dehydration

Discharge Planning

  • Follow up visit
  • Medications, when, and how to take them.
  • Medication side effect and when to call the provider
  • Monitor laboratory parameters as advised by the clinician
  • Monitor for infection

Pearls and Other issues

Symptoms of Addison disease can be nonspecific and, therefore, can be difficult to recognize. A high index of suspicion is required to make this diagnosis. The acute presentation includes cardiovascular collapse and hemodynamic instability.

In the Addisonian crisis, treatment is a priority and should not be delayed for diagnostic confirmation; delayed treatment can be fatal.

Glucocorticoid doses should be doubled in the presence of fever, infection, or other stresses.



(Click Image to Enlarge)
Addison's Disease symptoms
Addison's Disease symptoms
StatPearls Publishing Illustration
Details

Nurse Editor

Lisa M. Haddad

Author

Sadaf Munir

Editor:

Muhammad Waseem

Updated:

5/8/2023 6:09:09 PM

References

[1]

Yamamoto T. Latent Adrenal Insufficiency: Concept, Clues to Detection, and Diagnosis. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2018 Aug:24(8):746-755. doi: 10.4158/EP-2018-0114. Epub 2018 Aug 7     [PubMed PMID: 30084678]

[2]

Choudhury S, Meeran K. Glucocorticoid replacement in Addison disease. Nature reviews. Endocrinology. 2018 Sep:14(9):562. doi: 10.1038/s41574-018-0049-6. Epub     [PubMed PMID: 29930339]

[3]

Bancos I, Hahner S, Tomlinson J, Arlt W. Diagnosis and management of adrenal insufficiency. The lancet. Diabetes & endocrinology. 2015 Mar:3(3):216-26. doi: 10.1016/S2213-8587(14)70142-1. Epub 2014 Aug 3     [PubMed PMID: 25098712]

[4]

Michels AW, Eisenbarth GS. Immunologic endocrine disorders. The Journal of allergy and clinical immunology. 2010 Feb:125(2 Suppl 2):S226-37. doi: 10.1016/j.jaci.2009.09.053. Epub     [PubMed PMID: 20176260]

[5]

Fischli S. [CME: Adrenal Insufficiency]. Praxis. 2018 Jun:107(13):717-725. doi: 10.1024/1661-8157/a002982. Epub     [PubMed PMID: 29921185]

[6]

Singh G, Jialal I. Polyglandular Autoimmune Syndrome Type II. StatPearls. 2023 Jan:():     [PubMed PMID: 30252248]

[7]

Collin P, Kaukinen K, Välimäki M, Salmi J. Endocrinological disorders and celiac disease. Endocrine reviews. 2002 Aug:23(4):464-83     [PubMed PMID: 12202461]

[8]

Bachmeier CAE, Malabu U. Rare case of meningococcal sepsis-induced testicular failure, primary hypothyroidism and hypoadrenalism: Is there a link? BMJ case reports. 2018 Sep 15:2018():. pii: bcr-2018-224437. doi: 10.1136/bcr-2018-224437. Epub 2018 Sep 15     [PubMed PMID: 30219775]

[9]

Mayo J, Collazos J, Martínez E, Ibarra S. Adrenal function in the human immunodeficiency virus-infected patient. Archives of internal medicine. 2002 May 27:162(10):1095-8     [PubMed PMID: 12020177]

[10]

Harris P, Bennett A. Waterhouse-Friderichsen syndrome. The New England journal of medicine. 2001 Sep 13:345(11):841     [PubMed PMID: 11556316]

[11]

Kirkgoz T, Guran T. Primary adrenal insufficiency in children: Diagnosis and management. Best practice & research. Clinical endocrinology & metabolism. 2018 Aug:32(4):397-424. doi: 10.1016/j.beem.2018.05.010. Epub 2018 Jun 6     [PubMed PMID: 30086866]

[12]

Santosh Rai PV, Suresh BV, Bhat IG, Sekhar M, Chakraborti S. Childhood adrenoleukodystrophy - Classic and variant - Review of clinical manifestations and magnetic resonance imaging. Journal of pediatric neurosciences. 2013 Sep:8(3):192-7. doi: 10.4103/1817-1745.123661. Epub     [PubMed PMID: 24470810]

[13]

Westra SJ, Zaninovic AC, Hall TR, Kangarloo H, Boechat MI. Imaging of the adrenal gland in children. Radiographics : a review publication of the Radiological Society of North America, Inc. 1994 Nov:14(6):1323-40     [PubMed PMID: 7855344]

[14]

Espinosa G, Santos E, Cervera R, Piette JC, de la Red G, Gil V, Font J, Couch R, Ingelmo M, Asherson RA. Adrenal involvement in the antiphospholipid syndrome: clinical and immunologic characteristics of 86 patients. Medicine. 2003 Mar:82(2):106-18     [PubMed PMID: 12640187]

[15]

Tucker WS Jr, Snell BB, Island DP, Gregg CR. Reversible adrenal insufficiency induced by ketoconazole. JAMA. 1985 Apr 26:253(16):2413-4     [PubMed PMID: 3981770]

[16]

Hartle AJ, Peel PH. Etomidate puts patients at risk of adrenal crisis. BMJ (Clinical research ed.). 2012 Nov 6:345():e7444. doi: 10.1136/bmj.e7444. Epub 2012 Nov 6     [PubMed PMID: 23131303]

[17]

Thompson Bastin ML, Baker SN, Weant KA. Effects of etomidate on adrenal suppression: a review of intubated septic patients. Hospital pharmacy. 2014 Feb:49(2):177-83. doi: 10.1310/hpj4902-177. Epub     [PubMed PMID: 24623871]

[18]

Charmandari E, Nicolaides NC, Chrousos GP. Adrenal insufficiency. Lancet (London, England). 2014 Jun 21:383(9935):2152-67. doi: 10.1016/S0140-6736(13)61684-0. Epub 2014 Feb 4     [PubMed PMID: 24503135]

[19]

Burton C, Cottrell E, Edwards J. Addison's disease: identification and management in primary care. The British journal of general practice : the journal of the Royal College of General Practitioners. 2015 Sep:65(638):488-90. doi: 10.3399/bjgp15X686713. Epub     [PubMed PMID: 26324491]

[20]

Erichsen MM, Løvås K, Skinningsrud B, Wolff AB, Undlien DE, Svartberg J, Fougner KJ, Berg TJ, Bollerslev J, Mella B, Carlson JA, Erlich H, Husebye ES. Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a Norwegian registry. The Journal of clinical endocrinology and metabolism. 2009 Dec:94(12):4882-90. doi: 10.1210/jc.2009-1368. Epub 2009 Oct 26     [PubMed PMID: 19858318]

[21]

Bouachour G, Tirot P, Varache N, Gouello JP, Harry P, Alquier P. Hemodynamic changes in acute adrenal insufficiency. Intensive care medicine. 1994:20(2):138-41     [PubMed PMID: 8201094]

[22]

Dickstein G, Shechner C, Nicholson WE, Rosner I, Shen-Orr Z, Adawi F, Lahav M. Adrenocorticotropin stimulation test: effects of basal cortisol level, time of day, and suggested new sensitive low dose test. The Journal of clinical endocrinology and metabolism. 1991 Apr:72(4):773-8     [PubMed PMID: 2005201]

[23]

Samuels MH. Effects of variations in physiological cortisol levels on thyrotropin secretion in subjects with adrenal insufficiency: a clinical research center study. The Journal of clinical endocrinology and metabolism. 2000 Apr:85(4):1388-93     [PubMed PMID: 10770171]

[24]

Herndon J, Nadeau AM, Davidge-Pitts CJ, Young WF, Bancos I. Primary adrenal insufficiency due to bilateral infiltrative disease. Endocrine. 2018 Dec:62(3):721-728. doi: 10.1007/s12020-018-1737-7. Epub 2018 Sep 3     [PubMed PMID: 30178435]

[25]

Takahashi K, Kagami S, Kawashima H, Kashiwakuma D, Suzuki Y, Iwamoto I. Sarcoidosis Presenting Addison's Disease. Internal medicine (Tokyo, Japan). 2016:55(9):1223-8. doi: 10.2169/internalmedicine.55.5392. Epub 2016 May 1     [PubMed PMID: 27150885]

[26]

Guignat L. Therapeutic patient education in adrenal insufficiency. Annales d'endocrinologie. 2018 Jun:79(3):167-173. doi: 10.1016/j.ando.2018.03.002. Epub 2018 Mar 29     [PubMed PMID: 29606279]

[27]

Chanson P, Guignat L, Goichot B, Chabre O, Boustani DS, Reynaud R, Simon D, Tabarin A, Gruson D, Reznik Y, Raffin Sanson ML. Group 2: Adrenal insufficiency: screening methods and confirmation of diagnosis. Annales d'endocrinologie. 2017 Dec:78(6):495-511. doi: 10.1016/j.ando.2017.10.005. Epub 2017 Nov 23     [PubMed PMID: 29174200]

[28]

Wass JA, Arlt W. How to avoid precipitating an acute adrenal crisis. BMJ (Clinical research ed.). 2012 Oct 9:345():e6333. doi: 10.1136/bmj.e6333. Epub 2012 Oct 9     [PubMed PMID: 23048013]

[29]

Amrein K, Martucci G, Hahner S. Understanding adrenal crisis. Intensive care medicine. 2018 May:44(5):652-655. doi: 10.1007/s00134-017-4954-2. Epub 2017 Oct 26     [PubMed PMID: 29075801]

[30]

Arlt W, Society for Endocrinology Clinical Committee. SOCIETY FOR ENDOCRINOLOGY ENDOCRINE EMERGENCY GUIDANCE: Emergency management of acute adrenal insufficiency (adrenal crisis) in adult patients. Endocrine connections. 2016 Sep:5(5):G1-G3     [PubMed PMID: 27935813]

[31]

Oelkers W, Diederich S, Bähr V. Diagnosis and therapy surveillance in Addison's disease: rapid adrenocorticotropin (ACTH) test and measurement of plasma ACTH, renin activity, and aldosterone. The Journal of clinical endocrinology and metabolism. 1992 Jul:75(1):259-64     [PubMed PMID: 1320051]

[32]

Michels A, Michels N. Addison disease: early detection and treatment principles. American family physician. 2014 Apr 1:89(7):563-8     [PubMed PMID: 24695602]

[33]

Bornstein SR, Allolio B, Arlt W, Barthel A, Don-Wauchope A, Hammer GD, Husebye ES, Merke DP, Murad MH, Stratakis CA, Torpy DJ. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. The Journal of clinical endocrinology and metabolism. 2016 Feb:101(2):364-89. doi: 10.1210/jc.2015-1710. Epub 2016 Jan 13     [PubMed PMID: 26760044]

[34]

Chantzichristos D, Eliasson B, Johannsson G. MANAGEMENT OF ENDOCRINE DISEASE Disease burden and treatment challenges in patients with both Addison's disease and type 1 diabetes mellitus. European journal of endocrinology. 2020 Jul:183(1):R1-R11. doi: 10.1530/EJE-20-0052. Epub     [PubMed PMID: 32299062]

[35]

Zelissen PM, Bast EJ, Croughs RJ. Associated autoimmunity in Addison's disease. Journal of autoimmunity. 1995 Feb:8(1):121-30     [PubMed PMID: 7734032]

[36]

Hoek A, Schoemaker J, Drexhage HA. Premature ovarian failure and ovarian autoimmunity. Endocrine reviews. 1997 Feb:18(1):107-34     [PubMed PMID: 9034788]

[37]

Milenkovic A, Markovic D, Zdravkovic D, Peric T, Milenkovic T, Vukovic R. Adrenal crisis provoked by dental infection: case report and review of the literature. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2010 Sep:110(3):325-9. doi: 10.1016/j.tripleo.2010.04.025. Epub 2010 Jul 31     [PubMed PMID: 20674414]