Septic Shock

Overview

4.6 out of 5 (30 Reviews)

Credits

1.50

Post Assessment Questions

12

Start Date

1 Mar 2023

Last Review Date

12 Jun 2023

Expiration Date

28 Feb 2026

Estimated Time To Finish

90 Minutes

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Activity Description

Sepsis syndromes span a clinical continuum with variable prognoses. Septic shock, the most severe complication of sepsis, carries a high mortality. Septic shock occurs in response to an inciting agent, which causes both pro-inflammatory and anti-inflammatory immune system activation. This occurs in concert with the activation of monocytes, macrophages, and neutrophils that interact with the endothelium through pathogen recognition receptors and lead to further involvement of cytokines, proteases, kinins, reactive oxygen species, and nitric oxide. As the primary site of this response, the endothelium not only suffers microvascular injury but also activates the coagulation and complement cascades which further exacerbate the vascular injury, leading to capillary leakage. This cascade of events is responsible for the clinical signs and symptoms of sepsis and progression from sepsis to septic shock. Striking a balance between pro-inflammatory responses, which help eradicate the invading microorganism, and anti-inflammatory signals, which keep the inflammatory cascade in check, ultimately determines the degree of morbidity and/or mortality of patients with sepsis. Judicious and early antimicrobial administration, sepsis care bundle use, and early goal-directed therapies have significantly and positively impacted sepsis-related mortality. However, early identification remains the best therapeutic tool for sepsis treatment and management. This activity describes the evaluation and management of septic shock and highlights the role of the interprofessional team in enhancing care delivery for affected patients.

Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Review the causes of septic shock.
  • Describe the pathophysiology of septic shock.
  • Outline the treatment options for septic shock.
  • Explain the importance of improving care coordination amongst interprofessional team members to improve outcomes for patients affected by septic shock.

Disclosures

StatPearls requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. None of the planners of this educational activity have any relevant financial relationships to disclose.

COMMERCIAL SUPPORT: This activity has received NO commercial support.

Continuing Education Accreditation Information

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.50 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content in the activity.
  4. Choose the best answer to each activity test question. To receive credit, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment.
  6. Obtain a certificate.

For information on the applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

Disclaimer

Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearlsand and Quillen College of Medicine, East Tennessee State University reserve the right to cancel any course due to unforeseen circumstances. StatPearls andQuillen College of Medicine, East Tennessee State University will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Medium or Media Used:

  • Computer Requirements: Internet Access
  • E-mail Address

Equal Opportunity

  • StatPearls andQuillen College of Medicine, East Tennessee State University are Equal Opportunity/Affirmative Action/Equal Access Institutions. 

 

 
 

Reviews

Michael S. on 12/20/2020

Denise B. on 5/14/2021

i dont like you are makeing me do these evaluation to get the certificate

Rafael J. on 6/16/2021

Robert R. on 7/28/2021

Lisa S. on 8/13/2021

Has to include the use of hemodynamic monitoring such as PPV, PiCCO, and PAC, ultrasonography

Thiago C. on 9/10/2021

Linda B. on 9/2/2021

Eileen M. on 9/14/2021

John M. on 10/6/2021

saurabh t. on 9/5/2022

Jafet B. on 11/9/2021

Melissa H. on 1/2/2022

Dr.Mallikarjun K. on 1/20/2022

Thomas B. on 9/10/2022

Meldyne H. on 10/3/2022

Alok P. on 12/11/2022

reno l. on 12/11/2022

Philip S. on 12/18/2022

Dr.NIRMALA M. on 1/2/2023

Mary K. on 1/28/2023

Matthew N. on 1/31/2023

evan s. on 3/4/2023

Michelle N. on 3/26/2023

Deborah B. on 3/7/2023

Melanie P. on 3/19/2023

Alexa R. on 3/26/2023

Matthew S. on 4/8/2023

Ali I. on 5/31/2023

Lily L. on 7/4/2023

Ann G. on 8/22/2023

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