Warfarin Toxicity

Overview

4.6 out of 5 (16 Reviews)

Credits

1.50

Post Assessment Questions

11

Start Date

1 Mar 2023

Last Review Date

17 Jul 2023

Expiration Date

28 Feb 2026

Estimated Time To Finish

90 Minutes


 
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Activity Description

Warfarin is a vitamin K antagonist used as an anticoagulant used for treatment and prevention of a variety of coagulopathic and thromboembolic disorders. While it was initially marketed as a rodenticide, it has been used as a medication for more than a half-century. Superwarfarins are now also used as pesticides and should be recognized as having potential to cause warfarin toxicity. They are one hundred times more potent than warfarin. Toxicity can occur due to intentional overdose, unintentional overdose, and pediatric ingestion. Intentional overdose has been noted to be relatively rare; a 25-year long survey involving 2 tertiary care centers with toxicology services reported a total of 22 intentional overdoses in adults. Unintentional overdose or toxicity can occur through various mechanisms such as during the initial dose titration phase, with changes in diet that affect the medication potency, due to interactions with other medications, or secondary to metastatic liver disease. This activity describes the pathophysiology of warfarin toxicity and highlights the role of the interprofessional team in its management.

Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Describe the presentation of a patient with warfarin toxicity.
  • Summarize the causes of warfarin toxicity.
  • Outline the treatment options for warfarin toxicity.
  • Explain the importance of improving care coordination amongst interprofessional team members to improve outcomes for patients affected by warfarin toxicity.

Disclosures

StatPearls requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. None of the planners of this educational activity have any relevant financial relationships to disclose.

COMMERCIAL SUPPORT: This activity has received NO commercial support.

Continuing Education Accreditation Information

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.50 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content in the activity.
  4. Choose the best answer to each activity test question. To receive credit, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment.
  6. Obtain a certificate.

For information on the applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

Disclaimer

Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearlsand and Quillen College of Medicine, East Tennessee State University reserve the right to cancel any course due to unforeseen circumstances. StatPearls andQuillen College of Medicine, East Tennessee State University will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Medium or Media Used:

  • Computer Requirements: Internet Access
  • E-mail Address

Equal Opportunity

  • StatPearls andQuillen College of Medicine, East Tennessee State University are Equal Opportunity/Affirmative Action/Equal Access Institutions. 

 

 
 

Reviews

Kathryn T. on 9/7/2021

Emmy K. on 5/11/2022

Louie L. on 8/16/2022

Matthew S. on 9/7/2022

Sanjeev S. on 11/11/2022

Great

Kenneth R. on 12/10/2022

none

shawna v. on 12/20/2022

Nicole M. on 12/31/2022

Natalie p. on 1/2/2023

Deborah V. on 2/23/2023

Sharon B. on 2/12/2023

Theodore K. on 5/17/2023

Janet P. on 5/26/2023

Corazon B. on 6/26/2023

Dr Sruthi G. on 7/27/2023

Terry P. on 8/12/2023

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