Hematopoietic Stem Cell Transplantation in Sickle Cell Disease

Overview

4.3 out of 5 (9 Reviews)

Credits

1.00

Post Assessment Questions

5

Start Date

1 Mar 2023

Last Review Date

19 Jul 2023

Expiration Date

28 Feb 2026

Estimated Time To Finish

60 Minutes


 
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Activity Description

Since the Sickle Cell Anemia Act, steady progress has been made in the screening and treatment of sickle cell disease. Despite the development of new medical therapies, sickle cell disease remains an incurable condition for most affected individuals. Hematopoietic stem cell transplantation represents the only currently available curative option for individuals living with sickle cell disease. Hematopoietic stem cell transplantation may be autologous, requiring genetic modification of the patient's stem cells to correct the genetic mutation characteristic of sickle cell disease, or allogeneic, involving replacement of the defective stem cells with healthy stem cells from a suitable donor. Although HSCT is curative for most patients, the procedure is associated with significant toxicities and occasionally fatal complications. Care must be exercised when selecting patients for HSCT. This activity reviews the therapeutic role of HSCT in sickle cell disease and highlights the role of the interprofessional team in caring for patients who undergo the procedure.


Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify patients with sickle cell disease who may be candidates for hematopoietic stem cell transplantation based on their clinical history.
  • Assess and manage the complications of hematopoietic stem cell transplantation in sickle cell disease.
  • Effectively counsel patients with sickle cell disease and their caregivers about the risks and benefits of hematopoietic stem cell transplantation.
  • Develop and implement interprofessional team strategies to improve outcomes for patients with sickle cell disease undergoing hematopoietic stem cell transplantation.

Disclosures

StatPearls requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. None of the planners of this educational activity have any relevant financial relationships to disclose.

COMMERCIAL SUPPORT: This activity has received NO commercial support.

Continuing Education Accreditation Information

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.00 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content in the activity.
  4. Choose the best answer to each activity test question. To receive credit, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment.
  6. Obtain a certificate.

For information on the applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

Disclaimer

Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearlsand and Quillen College of Medicine, East Tennessee State University reserve the right to cancel any course due to unforeseen circumstances. StatPearls andQuillen College of Medicine, East Tennessee State University will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Medium or Media Used:

  • Computer Requirements: Internet Access
  • E-mail Address

Equal Opportunity

  • StatPearls andQuillen College of Medicine, East Tennessee State University are Equal Opportunity/Affirmative Action/Equal Access Institutions. 

 

 
 

Reviews

MOSFER A. on 9/4/2022

Micah L. on 12/28/2021

Jennifer K. on 3/2/2022

Dorthya D. on 3/27/2022

chandra d. on 6/26/2022

Samantha h. on 8/28/2022

Rita B. on 9/11/2022

Khelsea C. on 12/16/2022

Dr Sruthi G. on 6/20/2023

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