Valproate Toxicity

Overview

4.9 out of 5 (11 Reviews)

Credits

1.50

Post-Assessment Questions

9

Start Date

1 Sep 2023

Last Review Date

6 May 2024

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes


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Activity Description

Valproate toxicity results from an excessive accumulation of valproic acid in the body, often triggered by factors like high dosages, rapid dose adjustments, or interactions with other medications. Symptoms vary widely, including gastrointestinal distress symptoms such as nausea and vomiting, neurological manifestations like drowsiness, confusion, and, in severe cases, coma or fatality. Timely identification of risk factors and early symptom recognition is pivotal for intervening and mitigating adverse consequences. Treatment strategies involve a multifaceted approach, including supportive care to manage symptoms and specific interventions like L-carnitine therapy or hemodialysis to remove excess valproic acid from the bloodstream.

Through this course, participants better understand valproate toxicity comprehensively, including proficient identification of risk factors, thorough patient assessment techniques, and implementing appropriate diagnostic and therapeutic measures. Additionally, collaborating with an interprofessional team is emphasized, as this enhances patient outcomes significantly by facilitating seamless communication and coordination across various healthcare disciplines. By leveraging the expertise and resources of diverse specialists, patient care is optimized, ensuring timely and targeted interventions that improve safety and clinical effectiveness.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Screen patients for valproate toxicity, particularly hypoalbuminemic individuals or those exhibiting persistent symptoms despite normal total valproate levels.

  • Implement appropriate diagnostic and therapeutic measures for patients suspected of valproate toxicity, such as obtaining unbound valproate levels and initiating L-carnitine therapy or hemodialysis when indicated.

  • Differentiate between symptoms of valproate toxicity and other medical conditions to facilitate accurate diagnosis and timely intervention.

  • Collaborate with interprofessional teams to ensure comprehensive patient care, leveraging expertise from various specialties to optimize outcomes.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Anesthesiology: This activity contributes to the CME component of the American Board of Anesthesiology’s redesigned Maintenance of Certification in AnesthesiologyTM (MOCA®) program, known as MOCA 2.0®. Please consult the ABA website, www.theABA.org, for a list of all MOCA 2.0 requirements.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Pediatrics: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 1.50 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

American Board of Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Preeti P. on 6/15/2021

Caleb P. on 7/22/2021

reno l. on 12/11/2022

Meghanne R. on 2/21/2023

Ryan P. on 10/3/2023

Stephanie H. on 5/15/2024

Andrew F. on 2/18/2025

Brianna P. on 12/31/2023

Deborah V. on 5/13/2023

Terry P. on 12/10/2024

Cruz G. on 12/16/2024

Unlimited Physician CME

Stay up to date on the latest medical knowledge with 6742 CME activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 8014 hours of CME.

Learn About Lifetime CME

6 Month Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$199 per half year per user

1 Year Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$299 per 1 year per user